Natural selection on the Drosophila antimicrobial immune system
نویسندگان
چکیده
منابع مشابه
Natural selection on the Drosophila antimicrobial immune system.
The evolutionary dynamics of immune defenses have long attracted interest because of the special role the immune system plays in mediating the antagonistic interaction between hosts and pathogens. The antimicrobial immune system of the fruit fly Drosophila melanogaster is genetically well characterized and serves as a valuable model for studying insect and human innate immune defenses. I review...
متن کاملNatural selection drives Drosophila immune system evolution.
Evidence from disparate sources suggests that natural selection may often play a role in the evolution of host immune system proteins. However, there have been few attempts to make general population genetic inferences on the basis of analysis of several immune-system-related genes from a single species. Here we present DNA polymorphism and divergence data from 34 genes thought to function in t...
متن کاملPervasive Natural Selection in the Drosophila Genome?
Over the past four decades, the predominant view of molecular evolution saw little connection between natural selection and genome evolution, assuming that the functionally constrained fraction of the genome is relatively small and that adaptation is sufficiently infrequent to play little role in shaping patterns of variation within and even between species. Recent evidence from Drosophila, rev...
متن کاملConvergent Balancing Selection on an Antimicrobial Peptide in Drosophila
Genes of the immune system often evolve rapidly and adaptively, presumably driven by antagonistic interactions with pathogens [1-4]. Those genes encoding secreted antimicrobial peptides (AMPs), however, have failed to exhibit conventional signatures of strong adaptive evolution, especially in arthropods (e.g., [5, 6]) and often segregate for null alleles and gene deletions [3, 4, 7, 8]. Further...
متن کاملEffects of Maternal Immune System Status on Neonate’s Immune System
Background: This study evaluated the effects of the maternal immune system stimulation or suppression during the pregnancy on the development of the neonate’s immune system.Methods: A total of 20 female rats were divided into four groups. The groups were treated using Leishmania major, Salmonella typhimurium, Tacrolimus, and sterilized normal saline. The animals were mated after 3-time tr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Opinion in Microbiology
سال: 2008
ISSN: 1369-5274
DOI: 10.1016/j.mib.2008.05.001